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Federal Grant Proposals, Simplified

Cayuse 424 is the industry standard for fast, accurate completion and submission of federal grant proposals. Premiere research institutions nationwide complete more than 15,000 online proposal submissions annually. With deployments in 8 weeks and renowned ease of use, Cayuse 424 users enjoy improved proposal success and a rapid return on investment — backed by the best customer support in the industry.


Seamless Data Sharing

Simplify research administration by seamlessly sharing data between the Cayuse Research Suite and your existing institutional business applications and eRA systems.

99.99% First-Time Submission Success

Get submissions right the first time with Cayuse 424’s advanced validation engine, which delivers over 1,500 real-time error checks for a 99.99% first-time success rate.

Streamline Multi-Project Proposals

Improve efficiency by streamlining the process of creating, reviewing, and submitting complex grants with an unlimited number of components.

Full Support for Federal Grants

System-to-system submission for grants posted by NIH, NSF, AHRQ, CDC, NIFA, ONR, CDMRP, DoD, and other federal agencies with full support for over 99% of opportunities.

Real-Time Budget Access

Create budgets online for federal and non-federal proposals, and gain real-time access to budget information without emailing documents. Auto-escalation & auto-calculation features simplify planning and tracking of current & future budgets.


Cayuse 424 helps University of California, Irvine meet its proposal and funding goals.

Listen to Nancy Lewis, Executive Director, Sponsored Projects, describe how Cayuse 424 helps the UCI stay on track and meet their goals.

research proposals submitted using Cayuse 424 in 2018


first-time success rate with 1,500+ real-time validations


of opportunities in fully covered

of U.S. federal funding submitted via S2S using Cayuse 424 in 2018

Submit Successfully

Make sure your submissions to and the sponsoring agency are received successfully on the first attempt. Cayuse 424 features an Advanced Validation Engine that ensures a 99% first-time success rate for all system-to-system submissions. During proposal development, the system performs real-time error checks for agency- and opportunity-specific rules, validations, and other business rules. Error warnings include hyperlinks to help you quickly resolve issues and submit error-free proposals every time.

Reduce Repetition

Eliminate as much data entry as possible and improve accuracy with Cayuse 424 Auto-Fill capabilities. Cayuse 424 stores institutional and personnel data, so when a proposal is created, information is conveniently pre-populated within the proposal or auto-filled from drop-down menus. Auto-Fill data includes biographical information, department and institutional information (such as DUNS # and addresses), plus rate, and salary information for simplifying budget creation.


Subaward Automation Improves Accuracy

Eliminate the error-prone challenge of manually folding subaward proposals and budgets into prime proposals. The Import Subaward feature ensures any changes made to a subaward automatically get carried forward to the prime proposal. Automation offers greater assurance of data accuracy when developing complex proposals that include one or more subawards.

Easy Access to Proposal Budgets

Create budgets online for federal and non-federal proposals with Cayuse 424. Your research team has real-time access to budget information in a single system without the need for additional tools and spreadsheets. With proposal and budgeting information available in a single place, research administrators can keep track of components better for easy reference and improved accuracy.


Secure, Convenient Storage

Easily attach documentation for a specific project when submitting required files to Cayuse 424 stores all source documents (e.g., the Word version of the PDF) and provides secure, online access to supporting files. With all proposal-related files stored within Cayuse 424, users can easily view, route, or print complete proposal documentation conveniently from any location at any time.

Connect Critical Data to External Systems in Real Time

Improve research efficiency, data accuracy, and compliance throughout the entire research project life cycle. Cayuse 424 APIs simplify post-award management, creating a bi-directional data exchange of proposal information with existing eRA systems. Cayuse Connect modules maintain a single, accurate version of your most important data by integrating Cayuse 424 with institutional business applications.

API Connect provides easy integration into post-award systems, preserving the value of your investment and reducing administrative tasks. With bi-directional data exchange of proposal information with existing eRA systems, you can maintain capital expenses and expedite S2S submissions to federal funding agencies.


Cayuse Connect modules — HR Connect, Data Connect, and SSO Connect — provide integration with Enterprise Resource Planning (ERP), Data Warehouse, and Authentication systems, improving efficiency, data accuracy, and compliance throughout the entire project life cycle.

Resubmit Without Duplicating Entries

Re-purpose large amounts of proposal information quickly and easily with the Copy/Transform function. With just the click of a button, you can eliminate duplicate data entry and save time.


Copy an entire proposal for re-submission without duplicating data. Quickly turn revised proposals to meet each funding cycle deadline.

Transform a proposal from one opportunity to another by transferring existing data to a different opportunity or a new version of the same opportunity, including any information or forms that remain the same. Re-purposing information from one opportunity to another allows institutions to increase their number of proposal submissions.

See why leading research organizations trust Cayuse to help them simplify their processes, mitigate compliance risk and increase collaboration.