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About Cayuse


Cayuse helps leading research organizations simplify their processes, mitigate compliance risk and increase collaboration by providing a full suite of best-in-class research administration solutions. We provide an integrated suite of intuitive software to manage the entire research portfolio, from sourcing funds to award close-out, all supported by industry-leading customer support.


Founded by PI’s who created the first software for proposal development.


Delivered the first system-to-system enterprise application for


Merged with Evisions, Inc.


Returned to independent operation with 100% of our resources focused on the research enterprise.


Building an eRA Ecosystem


universities, hospitals and research organizations served

experts who live and breathe research administration


focused on serving the needs of the research enterprise

of U.S. federal funding submitted via S2S using Cayuse 424 in 2018

How it All Began

The Cayuse Research ecosystem is based on the solutions first created by Dr. Chris Harker in 1994. He moved to Oregon in the early 1990’s and was an active researcher at Oregon Health Sciences University (OHSU).

Dr. Harker strongly believed there had to be an easier way to apply for grants which would allow more focus on the actual science. In response, Dr. Harker created the first Public Health service grant application software called Grant Slam. The software was a best-seller, proving very popular with thousands of investigators, helping them to produce their paper-based NIH grant proposals. In 2002, he received a Small Business Innovation Research (SBIR) grant and commercialized the groundbreaking Cayuse 424, which launched in 2006.

Cayuse became the first vendor to successfully communicate System-to-System with through its flagship Cayuse 424 solution.  With robust error validation, pre-population of common fields, automated budget calculations, and world-class support, Cayuse 424 quickly amassed a large and loyal customer base.  Today nearly 1/3 of the top 100 research institutions in the United States utilize the solution.

In 2012, Cayuse merged with Evisions, Inc. Five years later, Cayuse split from Evisions and became a standalone company once again.

Cayuse Today

In 2018, Cayuse acquired Process Pathways, Canada’s market-leading research administration software company. Cayuse also acquired IT Works-a leader in the development and implementation of effort, financials, and grant management solutions for universities, healthcare, and independent research institutions.

Cayuse also partnered with Ex Libris’ Pivot, a tool that provides researchers with a streamlined process to find funding and collaborate with colleagues.

In 2019, Cayuse acquired NTM Consulting Services, the provider of eSirius research compliance and facility management software serving Life Sciences research organizations.

Cayuse also partnered with infoReady, a software solution that streamlines the grant application review processes.

These acquisitions and partnerships have allowed Cayuse to develop an ecosystem of research administration solutions and provide an integrated suite of intuitive software to manage the entire research portfolio.

As Cayuse continues to focus on the Research Enterprise by increasing resources in R&D, new software will be introduced to the market and integration enhancements will continue to strengthen the ecosystem.